Study title: Impact of a Typhoid Conjugate Vaccine Campaign on Antimicrobial Prescribing in Harare, Zimbabwe

Lead researcher(s): Rudo Chingono, Justin Dixon, Katharina Kranzer

Funder(s): Wellcome Trust, UKAID, University of Oxford

Partner(s): London School of Hygiene and Tropical Medicine, University of Sheffield, Harare City Health

Background

Harare has experienced recurrent typhoid outbreaks. In 2019 a 1-week mass vaccination campaign was conducted using the Typbar-typhoid conjugate vaccine (Bharat Biotech, Hyderabad, India) across several high density suburbs in Harare aimed at controling the outbreak.

Study aim(s)

To investigate whether this typhoid conjugate vaccine campaign affected antimicrobial prescribing in children presenting to primary care in Harare, Zimbabwe.

Study design

In this mixed methods study, data for acute paediatric outpatient consultations between Jan 1, 2018, and March 31, 2020, were collected from five clinics in Harare. To contextualise findings, qualitative data were collected between April 20, 2021, and July 20, 2022, comprising ethnographic research (ie, workshops, surveys, observations, and interviews) in 14 clinics. Ethnographic data were used for thematic analysis.

Duration

June 2020 - June 2024